A genealogical estimate of genetic relationships
The application of genetic relationships among individuals, characterized by a genetic
relationship matrix (GRM), has far-reaching effects in human genetics. However, the current …
relationship matrix (GRM), has far-reaching effects in human genetics. However, the current …
Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing
X Sheng, L **a, JL Cahoon, DV Conti… - Human Genetics and …, 2023 - cell.com
Over the last two decades, the human reference genome has undergone multiple updates
as we complete a linear representation of our genome. Two versions of human references …
as we complete a linear representation of our genome. Two versions of human references …
Empowering GWAS Discovery through Enhanced Genotype Imputation
Genotype imputation, crucial in genomics research, often faces accuracy limitations, notably
for rarer variants. Leveraging data from the 1000 Genomes Project, TOPMed and UK …
for rarer variants. Leveraging data from the 1000 Genomes Project, TOPMed and UK …
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
M Zwyer, ZM Xu, A Ross, J Hella, M Sasamalo… - bioRxiv, 2024 - biorxiv.org
Infectious diseases have affected humanity for millennia and are among the strongest
selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted …
selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted …
Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
The risk and prognosis of tuberculosis (TB) are affected by both human and bacterial genetic
factors. To identify interacting human and bacterial genetic loci, we leveraged paired human …
factors. To identify interacting human and bacterial genetic loci, we leveraged paired human …