RNA-DNA triplex formation by long noncoding RNAs
Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …
processes through various mechanisms that are not fully understood. Proposed …
Natural product DNA major groove binders
PL Hamilton, DP Arya - Natural product reports, 2012 - pubs.rsc.org
Covering: 1980 to 2011 Major groove recognition of DNA by proteins utilizes the variation in
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …
New approaches toward recognition of nucleic acid triple helices
DP Arya - Accounts of chemical research, 2011 - ACS Publications
A DNA duplex can be recognized sequence-specifically in the major groove by an
oligodeoxynucleotide (ODN). The resulting structure is a DNA triple helix, or triplex. The …
oligodeoxynucleotide (ODN). The resulting structure is a DNA triple helix, or triplex. The …
Aminoglycoside− Nucleic acid interactions: remarkable stabilization of DNA and RNA triple helices by neomycin
DP Arya, RL Coffee, B Willis… - Journal of the American …, 2001 - ACS Publications
The stabilization of poly (dA)⊙ 2poly (dT) triplex, a 22-base DNA triplex, and poly (rA)⊙
2poly (rU) triple helix by neomycin is reported. The melting temperatures, the association …
2poly (rU) triple helix by neomycin is reported. The melting temperatures, the association …
Neomycin binding to Watson− Hoogsteen (W− H) DNA triplex groove: a model
DP Arya, L Micovic, I Charles, RL Coffee… - Journal of the …, 2003 - ACS Publications
Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple
helix. It stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor …
helix. It stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor …
Neomycin− neomycin dimer: an all-carbohydrate scaffold with high affinity for AT-rich DNA duplexes
A dimeric neomycin− neomycin conjugate 3 with a flexible linker, 2, 2′-(ethylenedioxy) bis
(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT …
(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT …
Thermodynamics of nucleic acid “shape readout” by an aminosugar
H **, E Davis, N Ranjan, L Xue, D Hyde-Volpe… - Biochemistry, 2011 - ACS Publications
Recognition of nucleic acids is important for our understanding of nucleic acid structure as
well as for our understanding of nucleic acid–protein interactions. In addition to the direct …
well as for our understanding of nucleic acid–protein interactions. In addition to the direct …
Neomycin-induced hybrid triplex formation
DP Arya, RL Coffee, I Charles - Journal of the American Chemical …, 2001 - ACS Publications
There has been considerable interest in the stability and specificity of recognition in triplexes
consisting of both RNA and DNA strands. Biologically important triplexes could be …
consisting of both RNA and DNA strands. Biologically important triplexes could be …
Synthesis and spectroscopic studies of the aminoglycoside (Neomycin)− Perylene conjugate binding to human telomeric DNA
Synthesis of a novel perylene− neomycin conjugate (3) and the properties of its binding to
human telomeric G-quadruplex DNA, 5′-d [AG3 (T2AG3) 3](4), are reported. Various …
human telomeric G-quadruplex DNA, 5′-d [AG3 (T2AG3) 3](4), are reported. Various …
Click dimers to target HIV TAR RNA conformation
A series of neomycin dimers have been synthesized using “click chemistry” with varying
functionality and length in the linker region to target the human immunodeficiency virus type …
functionality and length in the linker region to target the human immunodeficiency virus type …