Traumatic brain injury (TBI) is a major cause of death and disability. Despite its importance
in public health, there are presently no drugs to treat TBI. Many reasons underlie why drugs …

How memories persist is a fundamental neurobiological question. The most commonly
studied physiological model of memory is long-term potentiation (LTP). The molecular …

Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in
the generation of new neurons in the dentate gyrus throughout life,. Neurons that arise in …

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly
implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on …

Analogous to learning and memory storage, long-term potentiation (LTP) is divided into
induction and maintenance phases. Testing the hypothesis that the mechanism of LTP …

Aging is associated with cognitive decline and accumulation of senescent cells in various
tissues and organs. Senolytic agents such as dasatinib and quercetin (D+ Q) in combination …

The hippocampus is involved in segregating memories, an ability that utilizes the neural
process of pattern separation and allows for cognitive flexibility. We evaluated a proposed …

Although pain-related excessive fear is known to be a key factor in chronic pain disability,
which involves the anterior cingulate cortex (ACC), little is known about the downstream …

Cognitive control is the ability to coordinate multiple streams of information to prevent
confusion and select appropriate behavioral responses, especially when presented with …

It is now widely accepted that hippocampal neurogenesis underpins critical cognitive
functions, such as learning and memory. To assess the behavioral importance of adult-born …