Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction,.
However, the molecular mechanisms driving immune–fibroblast cell communication in …

Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Diabetes is a systemic disease in which patients with diabetes may develop peripheral
neuropathy of the lower extremities and peripheral vascular disease due to long-term …

Rationale: Clinical application of mesenchymal stem cells (MSCs) and MSC-derived
exosomes (MSC-Exos) to alleviate myocardial ischemia/reperfusion (I/R) injury is …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

Abstract Huang‐Qi (Astragali Radix) is an herbal tonic widely used in China and many other
countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus …