Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is
that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body …

Oxidized low-density lipoprotein (oxLDL) is known to activate inflammatory responses in a
variety of cells, especially macrophages and dendritic cells. Interestingly, much of the oxLDL …

Primary interaction of an intracellular bacterium with its host cell is initiated by activation of
multiple signaling pathways in response to bacterium recognition itself or as cellular …

Abstract CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in
humans. However, upon infection of the lamina propria this tolerogenic response is …

Innate immune sensors can recognize when host cells are irrevocably compromised by
pathogens, and in response can trigger programmed cell death (pyroptosis, apoptosis, and …

Autophagy and inflammasome complex assembly are physiological processes that control
homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway that degrades …

Treponema pallidum is the pathogen that causes syphilis, a sexually transmitted disease;
however, the pathogenic mechanism of this organism remains unclear. Tp92 is the only T …

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to
communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are …

Effective activation of macrophages through phagocytic Fcγ receptors (FcγR) has been
shown to require selenoprotein K (Selk). We set out to determine whether the FcγR …