Photothermal therapy (PTT) has received increasing attention due to its high selectivity, non-
invasiveness, negligible drug resistance, oxygen independence, and minimal side effects. In …

Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …

In neurons, but also in all other cells the complex proteostasis network is monitored and
tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly …

Human BAG (Bcl-2-associated athanogene) proteins form a family of antiapoptotic proteins
that currently consists of six members (BAG1–6) all sharing the BAG protein domain from …

Abstract Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-
chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 …

Nanomaterials-mediated photothermal therapy (PTT) often suffers from the fundamental
cellular defense mechanism of heat shock response which leads to therapeutic resistance of …

Mechanistic studies from cell culture and animal models have revealed critical roles for the
heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

Small interfering RNA (siRNA)-induced gene therapy has been recognized as a promising
avenue for effective cancer treatment, while easy enzymatic degradation, poor transfection …

4-Hydroxynonenal (HNE) is a pro-apoptotic electrophile generated during the spontaneous
decomposition of oxidized lipids. We have previously shown that HNE activates the …