Approximately 15% of cancers exhibit loss of the chromosomal locus 9p21. 3–the genomic
location of the tumour suppressor gene CDKN2A and the methionine salvage gene …

Breast cancer is the most common cancer diagnosed in women worldwide. Early-stage
breast cancer is curable in~ 70–80% of patients, while advanced metastatic breast cancer is …

Multiple cancers exhibit aberrant protein arginine methylation by both type I arginine
methyltransferases, predominately protein arginine methyltransferase 1 (PRMT1) and to a …

Expression of protein arginine methyltransferase 5 (PRMT5) is highly positively correlated to
DNA damage repair (DDR) and DNA replication pathway genes in many types of cancer …

Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour
initiation, metastasis and chemoresistance. Despite this, the mechanism by which BCSCs …

Pancreatic cancer is the deadliest malignancy with a poor response to chemotherapy but is
potentially indicated for ferroptosis therapy. Here we identified that cytoplasmic …

Background CFAP65 (cilia and flagella associated protein 65) is a fundamental protein in
the development and formation of ciliated flagella, but few studies have focused on its role in …

Protein arginine methylation, a post-translational modification (PTM), is fundamental in
regulating protein function and stability. Among the nine protein methyl transferases (PRMT) …

Synthetic lethality in MTAP-deleted tumors: a promising avenue through targeted disruption of
the protein methylation pathway - Annals of Oncology Skip to Main Content Skip to Main Menu …

Proteasome is an essential organelle in guarding cellular protein homeostasis. Here, we
report that inhibition of proteasome leads to alterations in DNA methylation patterns in …