Managing diabetes with nanomedicine: challenges and opportunities

O Veiseh, BC Tang, KA Whitehead… - Nature Reviews Drug …, 2015 - nature.com
Nanotechnology-based approaches hold substantial potential for improving the care of
patients with diabetes. Nanoparticles are being developed as imaging contrast agents to …

Advances in transdermal insulin delivery

Y Zhang, J Yu, AR Kahkoska, J Wang, JB Buse… - Advanced drug delivery …, 2019 - Elsevier
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes
and commonly used in advanced type 2 diabetes. Although subcutaneous insulin …

Nanotechnology for protein delivery: Overview and perspectives

M Yu, J Wu, J Shi, OC Farokhzad - Journal of controlled release, 2016 - Elsevier
Protein-based therapeutics have made a significant impact in the treatment of a variety of
important human diseases. However, given their intrinsically vulnerable structure and …

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

R Mo, T Jiang, J Di, W Tai, Z Gu - Chemical society reviews, 2014 - pubs.rsc.org
Insulin is essential for type 1 and advanced type 2 diabetics to maintain blood glucose levels
and prolong lives. The traditional administration requires frequent subcutaneous insulin …

Insulin transdermal delivery system for diabetes treatment using a biocompatible ionic liquid-based microemulsion

MR Islam, S Uddin, MR Chowdhury… - … Applied Materials & …, 2021 - ACS Publications
Since injection administration for diabetes is invasive, it is important to develop an effective
transdermal method for insulin. However, transdermal delivery remains challenging owing to …

[HTML][HTML] Transdermal drug delivery systems in diabetes management: a review

LC Ng, M Gupta - Asian journal of pharmaceutical sciences, 2020 - Elsevier
Diabetes mellitus is a chronic disease in which there is an insufficient production of insulin
by the pancreas, or the insulin produced is unable to be utilized effectively by the body …

Current development of chemical penetration enhancers for transdermal insulin delivery

V Sugumar, M Hayyan, P Madhavan, WF Wong… - Biomedicines, 2023 - mdpi.com
The use of the transdermal delivery system has recently gained ample recognition due to the
ability to deliver drug molecules across the skin membrane, serving as an alternative to …

Stimuli‐responsive delivery of therapeutics for diabetes treatment

J Yu, Y Zhang, H Bomba, Z Gu - Bioengineering & translational …, 2016 - Wiley Online Library
Diabetic therapeutics, including insulin and glucagon‐like peptide 1 (GLP‐1), are essential
for diabetic patients to regulate blood glucose levels. However, conventional treatments that …

Glucose and H 2 O 2 dual-sensitive nanogels for enhanced glucose-responsive insulin delivery

C Li, X Liu, Y Liu, F Huang, G Wu, Y Liu, Z Zhang… - Nanoscale, 2019 - pubs.rsc.org
Diabetes is a chronic metabolic disorder disease characterized by high blood glucose levels
and has become one of the most serious threats to human health. In recent decades, a …

A comprehensive review of the evolution of insulin development and its delivery method

V Sugumar, KP Ang, AF Alshanon, G Sethi, PVC Yong… - Pharmaceutics, 2022 - mdpi.com
The year 2021 marks the 100th anniversary of the momentous discovery of insulin. Through
years of research and discovery, insulin has evolved from poorly defined crude extracts of …