Towards enabling a cardiovascular digital twin for human systemic circulation using inverse analysis

NK Chakshu, I Sazonov, P Nithiarasu - Biomechanics and modeling in …, 2021 - Springer
An exponential rise in patient data provides an excellent opportunity to improve the existing
health care infrastructure. In the present work, a method to enable cardiovascular digital twin …

Numerical evaluation of the effectiveness of coronary revascularization

SS Simakov, TM Gamilov, F Liang… - Russian journal of …, 2021 - degruyter.com
In the present paper we construct the model of coronary flow which utilizes the patient's CT
data on both large CA and perfusion. We reconstruct large coronary vessels based on the …

Computational analysis of haemodynamic indices in synthetic atherosclerotic coronary netwroks

S Simakov, T Gamilov, F Liang, P Kopylov - Mathematics, 2021 - mdpi.com
Haemodynamic indices are widely used in clinical practice when deciding on a particular
type of treatment. Low quality of the computed tomography data and tachycardia complicate …

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific …

F Tajeddini, MR Nikmaneshi… - International Journal …, 2020 - Wiley Online Library
The objective of this paper is to apply computational fluid dynamic (CFD) as a
complementary tool for clinical tests to not only predict the present and future status of left …

Comparison of Instantaneous Wave‐Free Ratio (iFR) and Fractional Flow Reserve (FFR) with respect to their sensitivities to cardiovascular factors: a computational …

X Ge, Y Liu, Z Yin, S Tu, Y Fan… - Journal of …, 2020 - Wiley Online Library
While coronary revascularization strategies guided by instantaneous wave‐free ratio (iFR)
are, in general, noninferior to those guided by fractional flow reserve (FFR) with respect to …

Artificial intelligence approaches to predict coronary stenosis severity using non-invasive fractional flow reserve

JM Carson, NK Chakshu, I Sazonov… - Proceedings of the …, 2020 - journals.sagepub.com
Fractional flow reserve is the current reference standard in the assessment of the functional
impact of a stenosis in coronary heart disease. In this study, three models of artificial …

Computational analysis of hemodynamic indices based on personalized identification of aortic pulse wave velocity by a neural network

T Gamilov, F Liang, P Kopylov, N Kuznetsova, A Rogov… - Mathematics, 2023 - mdpi.com
Adequate personalized numerical simulation of hemodynamic indices in coronary arteries
requires accurate identification of the key parameters. Elastic properties of coronary vessels …

A novel method for calculating CTFFR based on the flow ratio between stenotic coronary and healthy coronary

L Yu, W Guo, W He, W Qin, M Zeng, S Wang - Computer Methods and …, 2023 - Elsevier
Background Epicardial coronary stenosis may lead to myocardial ischaemia, and the
resulting obstructive coronary artery disease is one of the leading causes of death. CT …

Uncertainty Quantification and Sensitivity Analysis for Non‐invasive Model‐Based Instantaneous Wave‐Free Ratio Prediction

C Dalmaso, FE Fossan, AT Bråten… - International Journal for …, 2025 - Wiley Online Library
The main objectives of this work are to validate a 1D‐0D unsteady solver with a distributed
stenosis model for the patient‐specific estimation of resting haemodynamic indices and to …

A multi-stage neural network approach for coronary 3D reconstruction from uncalibrated X-ray angiography images

K Iyer, BK Nallamothu, CA Figueroa, RR Nadakuditi - Scientific Reports, 2023 - nature.com
We present a multi-stage neural network approach for 3D reconstruction of coronary artery
trees from uncalibrated 2D X-ray angiography images. This method uses several binarized …