Purpose Chemotherapy with alternating vincristine-doxorubicin-cyclophosphamide and
ifosfamide-etoposide cycles and primary tumor treatment with surgery and/or radiation …

Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …

The granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the
production, survival and activation of neutrophilic granulocytes during both normal and …

Neutrophils play a major role in cancer biology and both pro-and antitumoral functions of
tumor-infiltrating neutrophils have been described. We have shown that tumors, by releasing …

Background Cancer stem cells (CSCs) are thought to be responsible for tumor regeneration
after chemotherapy, although direct confirmation of this remains forthcoming. We therefore …

Granulocyte-colony stimulating factor (G-CSF) is one of several cytokines that can expand
and mobilize haematopoietic precursor cells from bone marrow. In particular, G-CSF …

Purpose: Bv8, also known as prokineticin 2, has been recently shown to be a mediator of
myeloid cell–dependent tumor angiogenesis in mouse models. We wished to determine …

Background: New investigational agents and chemotherapy regimens including
cyclophosphamide+ topotecan, temozolomide+ irinotecan, and anti-IGF-1R antibodies in …

Background: Ovarian cancer remains a major cause of cancer mortality in women, with only
limited understanding of disease aetiology at the molecular level. Granulocyte colony …

The neural crest is a population of cells in the vertebrate embryo that gives rise to a wide
range of tissues and cell types, including components of the peripheral nervous system and …