Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules
F Plescia, B Maggio, G Daidone, D Raffa - European Journal of Medicinal …, 2021 - Elsevier
The quinazolinone nucleus represents, among the class of fused heterocycles, a very
important scaffold to obtain molecules with biological activities. A review of literature …
important scaffold to obtain molecules with biological activities. A review of literature …
Visible light photocatalytic aerobic oxygenation of indoles and pH as a chemoselective switch
C Zhang, S Li, F Bureš, R Lee, X Ye, Z Jiang - ACS Catalysis, 2016 - ACS Publications
An efficient chemodivergent strategy for visible light photocatalysis is developed. In the
presence of a dicyanopyrazine-derived chromophore (DPZ) photocatalyst, aerobic …
presence of a dicyanopyrazine-derived chromophore (DPZ) photocatalyst, aerobic …
Synthesis, SAR and molecular docking studies of benzo [d] thiazole-hydrazones as potential antibacterial and antifungal agents
GF Zha, J Leng, N Darshini, T Shubhavathi… - Bioorganic & medicinal …, 2017 - Elsevier
A series of new benzo [d] thiazole-hydrazones analogues were synthesized and screened
for their in vitro antibacterial and antifungal activities. The results revealed that compounds …
for their in vitro antibacterial and antifungal activities. The results revealed that compounds …
Molecular modeling, QSAR analysis and antimicrobial properties of Schiff base derivatives of isatin
A new series of novel Schiff bases has been designed, synthesized and tested for in vitro
antimicrobial activity. QSAR studies followed by antibacterial screening using broth dilution …
antimicrobial activity. QSAR studies followed by antibacterial screening using broth dilution …
Green synthesis, antibacterial evaluation and QSAR analysis of some isatin Schiff bases
Twelve isatin Schiff bases (1a-7a, 1b-5b) were prepared by reacting isatin and 5-
bromoisatin with different anilines using green chemistry (microwave (MW) and ultrasound …
bromoisatin with different anilines using green chemistry (microwave (MW) and ultrasound …
Synthesis of thiazole linked indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors
A series of thiazole linked indolyl-3-glyoxylamide derivatives were synthesized and
evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 …
evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 …
Synthesis of benzo [d] thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents
A series of new benzo [d] thiazole-hydrazones were synthesized and characterized by
analytical and spectroscopic techniques. All the compounds were screened for their in vitro …
analytical and spectroscopic techniques. All the compounds were screened for their in vitro …
Selective Oxidative Decarbonylative Cleavage of Unstrained C(sp3)–C(sp2) Bond: Synthesis of Substituted Benzoxazinones
A transition metal (TM)-free practical synthesis of biologically relevant benzoxazinones has
been established via a selective oxidative decarbonylative cleavage of an unstrained C (sp …
been established via a selective oxidative decarbonylative cleavage of an unstrained C (sp …
Synthesis of 6-substituted 3 (H)-quinazolin-4-ones and their antimicrobial activity
M Ziyadullaev, R Karimov, A Abdurazakhov… - Pharmaceutical …, 2023 - Springer
Three-step synthesis of 6-amino-3 (H)-quinazolin-4-ones has been performed. Initially, the
condensation of 3 (H)-quinazolin-4-one was carried out in the presence of anthranilic acid …
condensation of 3 (H)-quinazolin-4-one was carried out in the presence of anthranilic acid …