Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

Mast cells are not only necessary for allergic reactions, but recent findings indicate that they
are also involved in a variety of neuroinflammatory diseases, especially those worsened by …

Mast cells accumulate in the stroma surrounding certain tumors, especially mammary
adenocarcinoma, and molecules they secrete could benefit the tumor. These include …

The skin offers an ideally suited, clinically relevant model for studying the crossroads
between peripheral and systemic responses to stress. A 'brain–skin connection'with local …

Current evidence from clinical and laboratory studies confirms that mast cells play a central
role in the pathogenesis and pathophysiology of interstitial cystitis (IC). In this article, we …

Many skin disorders, such as atopic dermatitis and psoriasis, worsen during stress and are
associated with increased numbers and activation of mast cells which release vasoactive …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, but
recent findings implicate them in a variety of inflammatory diseases affecting different …