Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis
Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …
Benzimidazole: A milestone in the field of medicinal chemistry
In the last 2-3 decades, the broad research in the application of benzimidazole derivatives
made it important for mankind. Many scientists have worked on benzimidazole derivatives …
made it important for mankind. Many scientists have worked on benzimidazole derivatives …
Tunable Electrochemical C− N versus N− N Bond Formation of Nitrogen‐Centered Radicals Enabled by Dehydrogenative Dearomatization: Biological Applications
S Lv, X Han, JY Wang, M Zhou, Y Wu… - Angewandte Chemie …, 2020 - Wiley Online Library
Herein, an environmentally friendly electrochemical approach is reported that takes
advantage of the captodative effect and delocalization effect to generate nitrogen‐centered …
advantage of the captodative effect and delocalization effect to generate nitrogen‐centered …
A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+
Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized
via click chemistry, between different azide derivatives and substituted benzimidazole …
via click chemistry, between different azide derivatives and substituted benzimidazole …
Palladium-Catalyzed Electro-oxidative C–H Amination toward the Synthesis of Pyrido[1,2-a]benzimidazoles with Hydrogen Evolution
Z Duan, L Zhang, W Zhang, L Lu, L Zeng, R Shi… - ACS …, 2020 - ACS Publications
Transition-metal-catalyzed oxidative C–H/N–H coupling reaction is an important method to
construct C–N bonds. However, stoichiometric oxidants were usually necessary. Here, we …
construct C–N bonds. However, stoichiometric oxidants were usually necessary. Here, we …
New structural classes of antimalarials
Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …
Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …
biologically active compounds which are therapeutically useful agents in drug discovery and …
Regiospecific synthesis of 1, 2-disubstituted (hetero) aryl fused imidazoles with tunable fluorescent emission
D Zhao, J Hu, N Wu, X Huang, X Qin, J Lan… - Organic Letters, 2011 - ACS Publications
A palladium-catalyzed two or fourfold amination was established that allows regiospecific
synthesis of a diversity-oriented library of 1, 2-disubstituted (hetero) aryl fused imidazoles …
synthesis of a diversity-oriented library of 1, 2-disubstituted (hetero) aryl fused imidazoles …
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites
M Leshabane, GA Dziwornu, D Coertzen… - ACS Infectious …, 2021 - ACS Publications
The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …
concern. Therefore, new compounds that potentially have a novel target in various …
Copper-catalyzed inter-and intramolecular C–N bond formation: synthesis of benzimidazole-fused heterocycles
A Cu (II)-catalyzed, inter/intramolecular C–N bond formation for the synthesis of various
benzimidazole-fused heterocycles in a concise manner has been reported. The robustness …
benzimidazole-fused heterocycles in a concise manner has been reported. The robustness …