Advances on the merger of electrochemistry and transition metal catalysis for organic synthesis

CA Malapit, MB Prater, JR Cabrera-Pardo, M Li… - Chemical …, 2021 - ACS Publications
Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …

Benzimidazole: A milestone in the field of medicinal chemistry

MS Vasava, MN Bhoi, SK Rathwa… - Mini reviews in …, 2020 - ingentaconnect.com
In the last 2-3 decades, the broad research in the application of benzimidazole derivatives
made it important for mankind. Many scientists have worked on benzimidazole derivatives …

Tunable Electrochemical C− N versus N− N Bond Formation of Nitrogen‐Centered Radicals Enabled by Dehydrogenative Dearomatization: Biological Applications

S Lv, X Han, JY Wang, M Zhou, Y Wu… - Angewandte Chemie …, 2020 - Wiley Online Library
Herein, an environmentally friendly electrochemical approach is reported that takes
advantage of the captodative effect and delocalization effect to generate nitrogen‐centered …

A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+

A Djemoui, A Naouri, MR Ouahrani, D Djemoui… - Journal of Molecular …, 2020 - Elsevier
Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized
via click chemistry, between different azide derivatives and substituted benzimidazole …

Palladium-Catalyzed Electro-oxidative C–H Amination toward the Synthesis of Pyrido[1,2-a]benzimidazoles with Hydrogen Evolution

Z Duan, L Zhang, W Zhang, L Lu, L Zeng, R Shi… - ACS …, 2020 - ACS Publications
Transition-metal-catalyzed oxidative C–H/N–H coupling reaction is an important method to
construct C–N bonds. However, stoichiometric oxidants were usually necessary. Here, we …

New structural classes of antimalarials

GK Rathod, M Jain, KK Sharma, S Das, A Basak… - European journal of …, 2022 - Elsevier
Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

Regiospecific synthesis of 1, 2-disubstituted (hetero) aryl fused imidazoles with tunable fluorescent emission

D Zhao, J Hu, N Wu, X Huang, X Qin, J Lan… - Organic Letters, 2011 - ACS Publications
A palladium-catalyzed two or fourfold amination was established that allows regiospecific
synthesis of a diversity-oriented library of 1, 2-disubstituted (hetero) aryl fused imidazoles …

Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites

M Leshabane, GA Dziwornu, D Coertzen… - ACS Infectious …, 2021 - ACS Publications
The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …

Copper-catalyzed inter-and intramolecular C–N bond formation: synthesis of benzimidazole-fused heterocycles

S Rasheed, DN Rao, P Das - The Journal of Organic Chemistry, 2015 - ACS Publications
A Cu (II)-catalyzed, inter/intramolecular C–N bond formation for the synthesis of various
benzimidazole-fused heterocycles in a concise manner has been reported. The robustness …