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Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …
This bacterium is constantly evolving and poses complex challenges for clinicians, often …
Pathogenicity and virulence of Clostridioides difficile
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …
A Gram-negative-selective antibiotic that spares the gut microbiome
Infections caused by Gram-negative pathogens are increasingly prevalent and are typically
treated with broad-spectrum antibiotics, resulting in disruption of the gut microbiome and …
treated with broad-spectrum antibiotics, resulting in disruption of the gut microbiome and …
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Bile acids (BAs) mediate the crosstalk between human and microbial cells and influence
diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) …
diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) …
Safety and tolerability of SER-109 as an investigational microbiome therapeutic in adults with recurrent Clostridioides difficile infection: a phase 3, open-label, single …
Importance A safe and effective treatment for recurrentClostridioides difficileinfection (CDI) is
urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …
The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens
The human gastrointestinal tract hosts a diverse network of microorganisms, collectively
known as the microbiota that plays an important role in health and disease. For instance, the …
known as the microbiota that plays an important role in health and disease. For instance, the …
The surgical infection society revised guidelines on the management of intra-abdominal infection
Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …
Proton pump inhibitors alter the composition of the gut microbiota
Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production
and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux. They have been …
and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux. They have been …
Effects of antibiotics on gut microbiota
The gut microbiota influences essential human functions including digestion, energy
metabolism, and inflammation by modulating multiple endocrine, neural, and immune …
metabolism, and inflammation by modulating multiple endocrine, neural, and immune …
Probiotics for the prevention of pediatric antibiotic‐associated diarrhea
Background Antibiotics alter the microbial balance commonly resulting in antibiotic‐
associated diarrhea (AAD). Probiotics may prevent AAD via providing gut barrier, restoration …
associated diarrhea (AAD). Probiotics may prevent AAD via providing gut barrier, restoration …