An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …

GnRH is the key neuropeptide controlling reproductive function in all vertebrate species.
Two different neuroendocrine mechanisms have evolved among female mammals to …

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

What arouses an animal or human from an inactive, nonresponsive state to a condition of
activity and responsiveness? What are the biological mechanisms for this change? In this …

Reproductive function is coordinated by kisspeptin (Kiss) and GnRH neurons. Phoenixin-20
amide (PNX) is a recently described peptide found to increase GnRH-stimulated LH …

Pulsatile secretion of gonadotropin-releasing hormone (GnRH) release is an intrinsic
property of hypothalamic GnRH neurons. Pulse generation has been attributed to multiple …

It is now well known that different forms of GnRH coexist in the same vertebrate species. In
humans, two forms of GnRH have been identified so far. The first form corresponds to the …

To study the mechanism of LH-releasing hormone (LHRH) pulse generation, the olfactory
pit/placode and the migratory pathway of LHRH neurons from monkey embryos at …

The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but
the cellular mechanisms and network properties generating GnRH pulses are not well …

The pulsatile secretion of gonadotropin-releasing hormone (GnRH) from normal and
immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by …