Is it time to start transitioning from 2D to 3D cell culture?
Cell culture is an important and necessary process in drug discovery, cancer research, as
well as stem cell study. Most cells are currently cultured using two-dimensional (2D) …
well as stem cell study. Most cells are currently cultured using two-dimensional (2D) …
Modelling cancer in microfluidic human organs-on-chips
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
Advances in Spheroids and Organoids on a Chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
In vitro 3D models are advanced biological tools that have been established to overcome
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D …
[HTML][HTML] Targeting immune cells for cancer therapy
SY Gun, SWL Lee, JL Sieow, SC Wong - Redox biology, 2019 - Elsevier
Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …
immune cells playing a central role in smouldering inflammation in the tumor …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
Recent advances for cancer detection and treatment by microfluidic technology, review and update
N Bargahi, S Ghasemali, S Jahandar-Lashaki… - Biological Procedures …, 2022 - Springer
Numerous cancer-associated deaths are owing to a lack of effective diagnostic and
therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a …
therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a …
A microfluidic platform for cultivating ovarian cancer spheroids and testing their responses to chemotherapies
There is increasing interest in utilizing in vitro cultures as patient avatars to develop
personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media …
personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media …
Cancer-on-chip models for metastasis: importance of the tumor microenvironment
Abstract Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …
Engineering approaches for studying immune-tumor cell interactions and immunotherapy
This review describes recent research that has advanced our understanding of the role of
immune cells in the tumor microenvironment (TME) using advanced 3D in vitro models and …
immune cells in the tumor microenvironment (TME) using advanced 3D in vitro models and …