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From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …
Discovery and development of calcium channel blockers
In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …
Microneedle-mediated delivery of Ziconotide-loaded liposomes fused with exosomes for analgesia
K Song, Y Hao, X Tan, H Huang, L Wang… - Journal of Controlled …, 2023 - Elsevier
Ziconotide (ZIC) is an N-type calcium channel antagonist for treating severe chronic pain
that is intolerable, or responds poorly to the administration of other drugs, such as intrathecal …
that is intolerable, or responds poorly to the administration of other drugs, such as intrathecal …
Animal models of pain: diversity and benefits
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to develo** …
deepening of our knowledge on mechanisms that cause pain is a prerequisite to develo** …
[HTML][HTML] Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …
targeted by multipronged curative. Various omics technologies, with a high rate of data …
[HTML][HTML] Intranasal administration for pain: oxytocin and other polypeptides
Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat
conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with …
conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with …
Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study
F Wang, Z Yang, M Liu, Y Tao, Z Li, Z Wu… - International Journal of …, 2020 - Elsevier
A rotigotine (ROT)-loaded polymer micelles thermosensitive gel (ROT-PM-TSG) delivery
system was engineered to enhance the solubility of the drug, prolong the residence time …
system was engineered to enhance the solubility of the drug, prolong the residence time …
Lavender oil reduces depressive mood in healthy individuals and enhances the activity of single oxytocin neurons of the hypothalamus isolated from mice: a …
Background. The aim of the present study was to assess the effects of lavender oil inhalation
on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in …
on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in …
Fabrication and characterization of clozapine nanoemulsion sol–gel for intranasal administration
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However,
it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes …
it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes …
[PDF][PDF] Novel encapsulation of lycopene in niosomes and assessment of its anticancer activity
The lycopene is a naturally occurring bioactive constituent of Lycopersicum esculentum and
its use in the prevention of cancer and diabetes. Develo** effective therapy using a …
its use in the prevention of cancer and diabetes. Develo** effective therapy using a …