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Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …
microbiota. The past two decades have witnessed increasing interest in studying the gut …
[HTML][HTML] Intestinal epithelial cell metabolism at the interface of microbial dysbiosis and tissue injury
The intestinal epithelium represents the most regenerative tissue in the human body, located
in proximity to the dense and functionally diverse microbial milieu of the microbiome …
in proximity to the dense and functionally diverse microbial milieu of the microbiome …
Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has
been associated with alterations in the gut microbiome, ie, the microorganisms and their …
been associated with alterations in the gut microbiome, ie, the microorganisms and their …
The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis
M Heddes, B Altaha, Y Niu, S Reitmeier… - Nature …, 2022 - nature.com
Abstract Diurnal (ie., 24-hour) oscillations of the gut microbiome have been described in
various species including mice and humans. However, the driving force behind these …
various species including mice and humans. However, the driving force behind these …
Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation
Multiple studies have implicated microbes in the development of inflammation, but the
mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in …
mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in …
[HTML][HTML] Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice
Ulcerative colitis (UC) is a relapsing and remitting inflammatory disease. Probiotics have a
potential beneficial effect on the prevention of UC onset and relapse in clinical trials …
potential beneficial effect on the prevention of UC onset and relapse in clinical trials …
The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis
Ferroptosis, a new type of cell death has been found to aggravate intestinal
ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut …
ischemia/reperfusion (I/R) injury. However, little is known about the changes of gut …
Metabolic influences of gut microbiota dysbiosis on inflammatory bowel disease
Inflammatory bowel diseases (IBD) are chronic medical disorders characterized by recurrent
gastrointestinal inflammation. While the etiology of IBD is still unknown, the pathogenesis of …
gastrointestinal inflammation. While the etiology of IBD is still unknown, the pathogenesis of …
The emerging roles of bacterial proteases in intestinal diseases
Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …
and have been implicated in several common gastrointestinal (GI) diseases. Although …
[HTML][HTML] Insights into gut dysbiosis: inflammatory diseases, obesity, and restoration approaches
A Acevedo-Román, N Pagán-Zayas… - International Journal of …, 2024 - mdpi.com
The gut microbiota is one of the most critical factors in human health. It involves numerous
physiological processes impacting host health, mainly via immune system modulation. A …
physiological processes impacting host health, mainly via immune system modulation. A …