Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in
cells and tissues of humans. Fatty acids are energy sources and membrane constituents …

Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Many complex biological programs are controlled at the level of gene transcription by DNA
binding transcription factors. Recent studies have revealed a novel mode of regulation by …

PPARγ coactivator 1α (PGC-1α) is a potent stimulator of mitochondrial biogenesis and
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …

Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is a member of a family of
transcription coactivators that plays a central role in the regulation of cellular energy …

Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as
inducible coregulators of nuclear receptors in the control of cellular energy metabolic …