Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

T Zhao, Y Wei, Y Zhu, Z **e, Q Hai, Z Li… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints.
Microbial infection is considered a crucial inducer of RA. Alterations in the composition of …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

The gut–joint axis in rheumatoid arthritis

MM Zaiss, HJ Joyce Wu, D Mauro, G Schett… - Nature Reviews …, 2021 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

[HTML][HTML] Molecular mimicry and autoimmunity

M Rojas, P Restrepo-Jiménez, DM Monsalve… - Journal of …, 2018 - Elsevier
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

S Lucas, Y Omata, J Hofmann, M Böttcher… - Nature …, 2018 - nature.com
Microbial metabolites are known to modulate immune responses of the host. The main
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …

Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases

Y Jiao, L Wu, ND Huntington, X Zhang - Frontiers in immunology, 2020 - frontiersin.org
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …

The role of the gut microbiome in systemic inflammatory disease

JC Clemente, J Manasson, JU Scher - Bmj, 2018 - bmj.com
The role of the gut microbiome in models of inflammatory and autoimmune disease is now
well characterized. Renewed interest in the human microbiome and its metabolites, as well …

[HTML][HTML] Role of microbiota short-chain fatty acids in the pathogenesis of autoimmune diseases

A Rasouli-Saravani, K Jahankhani, S Moradi… - Biomedicine & …, 2023 - Elsevier
There is emerging evidence that microbiota and its metabolites play an important role in
helath and diseases. In this regard, gut microbiota has been found as a crucial component …

Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes

KN Thompson, KS Bonham, NE Ilott… - Science translational …, 2023 - science.org
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has
been implicated in inflammatory conditions, but large-scale metagenomic evaluations have …