Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Glutamate is the most commonly engaged neurotransmitter in the mammalian central
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …
Synaptopathies: synaptic dysfunction in neurological disorders–A review from students to students
Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …
throughout the nervous system to adjust behavior to environmental stimuli and to control …
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
Rab GTPases and membrane trafficking in neurodegeneration
Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
E Taoufik, G Kouroupi, O Zygogianni… - Open …, 2018 - royalsocietypublishing.org
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …
synapse structure and function, and can be either the cause or the consequence in specific …
Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics
A Kalani, A Tyagi, N Tyagi - Molecular neurobiology, 2014 - Springer
Exosomes have emerged as prominent mediators of neurodegenerative diseases where
they have been shown to carry disease particles such as beta amyloid and prions from their …
they have been shown to carry disease particles such as beta amyloid and prions from their …
LRRK2 is involved in the IFN-γ response and host response to pathogens
LRRK2 was previously identified as a defective gene in Parkinson's disease, and it is also
located in a risk region for Crohn's disease. In this study, we aim to determine whether …
located in a risk region for Crohn's disease. In this study, we aim to determine whether …
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA …
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA …
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease
(PD), but the underlying pathophysiological mechanisms and the normal function of this …
(PD), but the underlying pathophysiological mechanisms and the normal function of this …