Depression in neurodegenerative diseases: Common mechanisms and current treatment options
CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …
cause of disability worldwide. This neurological condition is commonly associated with …
Advancement in the modelling and therapeutics of Parkinson's disease
SN Rai, P Singh - Journal of chemical neuroanatomy, 2020 - Elsevier
Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …
neuroprotective therapy available although significant development has been made in the …
Targeting thalamic circuits rescues motor and mood deficits in PD mice
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with
Parkinson's disease (PD), patients also experience motor learning impairments and non …
Parkinson's disease (PD), patients also experience motor learning impairments and non …
Impact of the secretome of human mesenchymal stem cells on brain structure and animal behavior in a rat model of Parkinson's disease
Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated
therapeutic benefits are mainly due to their secretome, which has been proposed as a …
therapeutic benefits are mainly due to their secretome, which has been proposed as a …
Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
[HTML][HTML] Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease
SL Nickels, J Modamio, B Mendes-Pinheiro… - Stem Cell Research, 2020 - Elsevier
The study of human midbrain development and midbrain related diseases, like Parkinson's
disease (PD), is limited by deficiencies in the currently available and validated laboratory …
disease (PD), is limited by deficiencies in the currently available and validated laboratory …
Cholinergic interneurons amplify thalamostriatal excitation of striatal indirect pathway neurons in Parkinson's disease models
A Tanimura, Y Du, J Kondapalli, DL Wokosin… - Neuron, 2019 - cell.com
The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in
the activity of striatal direct-and indirect-pathway spiny projection neurons (SPNs). Disease …
the activity of striatal direct-and indirect-pathway spiny projection neurons (SPNs). Disease …
Rodent models of Parkinson's disease: beyond the motor symptomatology
Parkinson's disease (PD) is classically characterized by motor symptoms; however, non-
motor symptoms (NMS) are increasingly recognized as relevant in disease-state, given the …
motor symptoms (NMS) are increasingly recognized as relevant in disease-state, given the …
Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies
TT Lai, B Gericke, M Feja, M Conoscenti… - npj Parkinson's …, 2023 - nature.com
Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …
Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in
the human midbrain causing motor dysfunctions. The exact mechanism behind …
the human midbrain causing motor dysfunctions. The exact mechanism behind …