Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in develo** cardiovascular diseases such as hypertension, atrial …

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more
than 5% of hepatocytes in the absence of excessive alcohol consumption and other …

Background Elevated serum urate levels are associated with progression of chronic kidney
disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the …

Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

This review article summarizes the relevant English literature on gout from 2010 through
April 2017. It emphasizes that the current epidemiology of gout indicates a rising prevalence …

Background The relative efficacy and safety of allopurinol and febuxostat when used
according to current guidelines for the treatment of hyperuricemia are unknown. This double …

Background Patients with chronic kidney disease (CKD) bear a substantial burden of
comorbidities leading to the prescription of multiple drugs and a risk of polypharmacy …

Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other
serious infections. Conversely, infection is the second most common cause of death in …

Hyperuricemia has long been recognized to be associated with increased cardiovascular
risk, including risk of develo** hypertension. Epidemiological findings suggest that the link …