Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …

Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can
augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to …

Objective Hepatocellular carcinima is one of the most common tumors in clinic and also one
of the leading causes of death from cancer worldwide. Quercetin shows significant effects on …

Autophagy is a cellular catabolic process critical for cell viability and homoeostasis.
Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates …

Abstract Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are widely reported as a pH-
sensitive drug delivery carrier with high loading capacity for tumor therapy. However, the …

The modulation of macroautophagy is now recognized as one of the hallmarks of cancer
cells. There is accumulating evidence that autophagy plays a role in the various stages of …

Autophagy is a complex process involved in several cell activities, including tissue growth,
differentiation, metabolic modulation, and cancer development. In prostate cancer …

Abstract Autophagy, or'self-eating', is an adaptive process that enables cells to cope with
metabolic, toxic, and even infectious stressors. Although the adaptive capability of …

Macroautophagy, a catabolic process of cellular self-digestion, is an important tumor cell
survival mechanism and a potential target in antineoplastic therapies. Recent discoveries …