Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

AC Dolphin - The Journal of physiology, 2016 - Wiley Online Library
Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Structure and Regulation of Voltage-Gated Ca2+ Channels

WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel

O Zhuchenko, J Bailey, P Bonnen, T Ashizawa… - Nature …, 1997 - nature.com
A polymorphic CAG repeat was identified in the human α1A voltage-dependent calcium
channel subunit. To test the hypothesis that expansion of this CAG repeat could be the …

Glutamine repeats and neurodegeneration

HY Zoghbi, HT Orr - Annual review of neuroscience, 2000 - annualreviews.org
A growing number of neurodegenerative diseases have been found to result from the
expansion of an unstable trinucleotide repeat. Over the past 6 years, researchers have …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

[PDF][PDF] Structure and function of voltage-gated ion channels

WA Catterall - Annual review of biochemistry, 1995 - perso.univ-rennes1.fr
The voltage-gated sodium, calcium, and potassium channels are responsible for the
generation of conducted electrical signals in neurons and other excitable cells. The …

Roles of N-Type and Q-Type Ca2+ Channels in Supporting Hippocampal Synaptic Transmission

DB Wheeler, A Randall, RW Tsien - Science, 1994 - science.org
Several types of calcium channels found in the central nervous system are possible
participants in triggering neurotransmitter release. Synaptic transmission between …

Calcium-channel antibodies in the Lambert–Eaton syndrome and other paraneoplastic syndromes

VA Lennon, TJ Kryzer, GE Griesmann… - … England Journal of …, 1995 - Mass Medical Soc
Background Voltage-gated calcium channels in small-cell lung carcinomas may initiate
autoimmunity in the paraneoplastic neuromuscular disorder Lambert–Eaton syndrome. The …

Exocytotic Ca2+ channels in mammalian central neurons

K Dunlap, JI Luebke, TJ Turner - Trends in neurosciences, 1995 - Elsevier
Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle
contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits …