Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …

Cytokines have a crucial role in the pathogenesis of inflammatory bowel diseases (IBDs),
such as Crohn's disease and ulcerative colitis, where they control multiple aspects of the …

Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel
disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

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Although very high levels of interleukin (IL)-1β are present in the intestines of patients
suffering from inflammatory bowel diseases (IBD), little is known about the contribution of IL …

The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

We have characterized the progressive stages of chronic intestinal inflammation that
develops spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in …

The perpetuation of inflammation in ulcerative colitis and Crohn's disease may be regulated
in part by an increased secretion of proinflammatory cytokines due to either an appropriate …

Introduction: Although the etiology of inflammatory bowel diseases (IBD) remains unknown,
accumulating evidence suggests that the intestinal tissue damage in these disorders is due …