Nucleosides for the treatment of respiratory RNA virus infections

PC Jordan, SK Stevens, J Deval - Antiviral Chemistry and …, 2018 - journals.sagepub.com
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus,
coronaviruses, and rhinoviruses are among the most common viruses causing mild …

Current methods for diagnosis of human coronaviruses: pros and cons

MR Benzigar, R Bhattacharjee, M Baharfar… - Analytical and …, 2021 - Springer
The current global fight against coronavirus disease (COVID-19) to flatten the transmission
curve is put forth by the World Health Organization (WHO) as there is no immediate …

Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription

CH Woo, S Jang, G Shin, GY Jung… - Nature Biomedical …, 2020 - nature.com
The control of viral outbreaks requires nucleic acid diagnostic tests that are sensitive, simple
and fast. Here, we report a highly sensitive and specific one-pot assay for the fluorescence …

Priming time: how cellular proteases arm coronavirus spike proteins

M Hoffmann, H Hofmann-Winkler… - Activation of viruses by host …, 2018 - Springer
Coronaviruses are enveloped RNA viruses that infect mammals and birds. Infection of
humans with globally circulating human coronaviruses is associated with the common cold …

[HTML][HTML] MERS-CoV infection: mind the public knowledge gap

A Bawazir, E Al-Mazroo, H Jradi, A Ahmed… - Journal of infection and …, 2018 - Elsevier
Abstract In August 2015, the Corona outbreak caused by Middle East respiratory syndrome
coronavirus (MERS-CoV) was the 9th episode since June 2012 in Saudi Arabia. Little is …

[HTML][HTML] Coronaviruses: is sialic acid a gate to the eye of cytokine storm? From the entry to the effects

P Wielgat, K Rogowski, K Godlewska, H Car - Cells, 2020 - mdpi.com
Coronaviruses (CoVs) are a diverse family of the enveloped human and animal viruses
reported as causative agents for respiratory and intestinal infections. The high pathogenic …

Immune response in COVID-19: What do we currently know?

DS Oliveira, NI Medeiros, JAS Gomes - Microbial pathogenesis, 2020 - Elsevier
In 2002/2003 there was a pandemic denominate SARS (severe acute respiratory
syndrome), caused by the SARS-CoV virus that belongs to the genera Betacoranavirus and …

MERS virus spike protein HTL-epitopes selection and multi-epitope vaccine design using computational biology

A Joshi, N Akhtar, NR Sharma, V Kaushik… - Journal of …, 2023 - Taylor & Francis
MERS-CoV, a zoonotic virus, poses a serious threat to public health globally. Thus, it is
imperative to develop an effective vaccination strategy for protection against MERS-CoV …

Emerging role of complement in COVID-19 and other respiratory virus diseases

MT **ao, CR Ellsworth, X Qin - Cellular and Molecular Life Sciences, 2024 - Springer
The complement system, a key component of innate immunity, provides the first line of
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …

Middle East Respiratory Syndrome (MERS) virus—pathophysiological axis and the current treatment strategies

AM Alnuqaydan, AG Almutary, A Sukamaran… - AAPS …, 2021 - Springer
Middle East respiratory syndrome (MERS) is a lethal respiratory disease with its first case
reported back in 2012 (Jeddah, Saudi Arabia). It is a novel, single-stranded, positive-sense …