Malnutrition in older adults—recent advances and remaining challenges

K Norman, U Haß, M Pirlich - Nutrients, 2021 - mdpi.com
Malnutrition in older adults has been recognised as a challenging health concern
associated with not only increased mortality and morbidity, but also with physical decline …

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

A Santoro, E Bientinesi, D Monti - Ageing research reviews, 2021 - Elsevier
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

How the ageing microenvironment influences tumour progression

M Fane, AT Weeraratna - Nature Reviews Cancer, 2020 - nature.com
Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

C Franceschi, P Garagnani, P Parini… - Nature Reviews …, 2018 - nature.com
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

LGPL Prata, IG Ovsyannikova, T Tchkonia… - Seminars in …, 2018 - Elsevier
Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

Inflammaging and 'Garb-aging'

C Franceschi, P Garagnani, G Vitale, M Capri… - Trends in Endocrinology …, 2017 - cell.com
'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging.
Inflammaging is macrophage centered, involves several tissues and organs, including the …

[HTML][HTML] Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

PC Calder, N Bosco, R Bourdet-Sicard, L Capuron… - Ageing research …, 2017 - Elsevier
Ageing of the global population has become a public health concern with an important socio-
economic dimension. Ageing is characterized by an increase in the concentration of …

Aging, inflammation and the environment

A Bektas, SH Schurman, R Sen, L Ferrucci - Experimental gerontology, 2018 - Elsevier
The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …