Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Hyperbolic deep neural networks: A survey

W Peng, T Varanka, A Mostafa, H Shi… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Recently, hyperbolic deep neural networks (HDNNs) have been gaining momentum as the
deep representations in the hyperbolic space provide high fidelity embeddings with few …

Gene–environment correlations across geographic regions affect genome-wide association studies

A Abdellaoui, CV Dolan, KJH Verweij, MG Nivard - Nature genetics, 2022 - nature.com
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

Grambank reveals the importance of genealogical constraints on linguistic diversity and highlights the impact of language loss

H Skirgård, HJ Haynie, DE Blasi, H Hammarström… - Science …, 2023 - science.org
While global patterns of human genetic diversity are increasingly well characterized, the
diversity of human languages remains less systematically described. Here, we outline the …

[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆

QM Anstee, R Darlay, S Cockell, M Meroni… - Journal of …, 2020 - Elsevier
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

E Elhaik - Scientific reports, 2022 - nature.com
Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …

Codiversification of gut microbiota with humans

TA Suzuki, JL Fitzstevens, VT Schmidt, H Enav… - Science, 2022 - science.org
The gut microbiomes of human populations worldwide have many core microbial species in
common. However, within a species, some strains can show remarkable population …

A method for genome-wide genealogy estimation for thousands of samples

L Speidel, M Forest, S Shi, SR Myers - Nature genetics, 2019 - nature.com
Abstract Knowledge of genome-wide genealogies for thousands of individuals would
simplify most evolutionary analyses for humans and other species, but has remained …

Tinnitus prevalence in Europe: a multi-country cross-sectional population study

R Biswas, A Lugo, MA Akeroyd, W Schlee… - The Lancet Regional …, 2022 - thelancet.com
Background Tinnitus prevalence studies report large variability across countries that might
be due to inconsistent research methods. Our study aimed to report a single Pan-European …

[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations

AR Martin, CR Gignoux, RK Walters, GL Wojcik… - The American Journal of …, 2017 - cell.com
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …