Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …

Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain
unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where …

Akkermansia muciniphila is a Gram-negative anaerobic mucus-layer-degrading bacterium
that colonizes the intestinal mucosa of humans and rodents. Metagenomic data have shown …

Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

Obesity is a global epidemic characterized by energy disequilibrium, metabolic disorder, fat
mass development, and chronic low-grade inflammation, which significantly affects the …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …