Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix,
behaving as a critical mechanism in preventing adherent-independent cell growth and …

MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate
protein-coding gene expression post-transcriptionally via base pairing between the 5 …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor …

Epithelial cancers make up the vast majority of cancer types and, during the transition from
benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de …

Anoikis is a programmed cell death occurring upon cell detachment from the correct
extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing …

The ability of a cancer cell to develop resistance to anoikis, a programmed cell death
process triggered by substratum detachment, is a critical step in the metastatic cascade …

The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …

In most carcinomas, invasion of malignant cells into surrounding tissues involves their
molecular reprogramming as part of an epithelial-to-mesenchymal transition (EMT). Mutation …