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Modelling cancer in microfluidic human organs-on-chips
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
Three-dimensional cell cultures in drug discovery and development
Y Fang, RM Eglen - Slas discovery: Advancing Life Sciences …, 2017 - journals.sagepub.com
The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform
In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
Modular microfluidics for life sciences
The advancement of microfluidics has enabled numerous discoveries and technologies in
life sciences. However, due to the lack of industry standards and configurability, the design …
life sciences. However, due to the lack of industry standards and configurability, the design …
A review of cell adhesion studies for biomedical and biological applications
Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …
importance in the development and maintenance of tissues. The mechanical interactions …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Organs-on-chips at the frontiers of drug discovery
Improving the effectiveness of preclinical predictions of human drug responses is critical to
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics
Distant metastasis, which results in> 90% of cancer-related deaths, is enabled by
hematogenous dissemination of tumor cells via the circulation. This requires the completion …
hematogenous dissemination of tumor cells via the circulation. This requires the completion …
Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
A key aspect of cancer metastases is the tendency for specific cancer cells to home to
defined subsets of secondary organs. Despite these known tendencies, the underlying …
defined subsets of secondary organs. Despite these known tendencies, the underlying …