Molecular mechanisms of gasdermin D pore-forming activity
The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …
The contribution of microglia to neuroinflammation in Parkinson's disease
K Badanjak, S Fixemer, S Smajić, A Skupin… - International Journal of …, 2021 - mdpi.com
With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …
In recent years, inflammatory processes have emerged as prominent contributors to the …
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
Biomarker of neuroinflammation in Parkinson's disease
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
The TNF receptor superfamily in co-stimulating and co-inhibitory responses
Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …
for coordinating multiple cell types into an effective host defense system against pathogens …
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
T Eguchi, T Kuwahara, M Sakurai… - Proceedings of the …, 2018 - National Acad Sciences
Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human
diseases, including Parkinson's disease and Crohn's disease, whereas LRRK2 deficiency …
diseases, including Parkinson's disease and Crohn's disease, whereas LRRK2 deficiency …
Innate and adaptive immunity in inflammatory bowel disease
A Geremia, P Biancheri, P Allan, GR Corazza… - Autoimmunity …, 2014 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …
Genetics and pathogenesis of inflammatory bowel disease
B Khor, A Gardet, RJ Xavier - Nature, 2011 - nature.com
Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …