The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

Autophagy is an essential, homeostatic process by which cells break down their own
components. Perhaps the most primordial function of this lysosomal degradation pathway is …

Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …

Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the
gastrointestinal tract with extraintestinal manifestations and associated immune disorders …

With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …

Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …