Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

The practical recommendations of the German Diabetes Society/Deutsche Diabetes
Gesellschaft (DDG) together with the German Society for Internal Medicine/Deutschen …

Pyroptosis is a form of programmed cell death initiated by inflammasomes and is critical for
immunity. SIRT1, a NAD+-dependent deacetylase, plays multiple roles in inflammatory …

Trastuzumab is the only approved targeted drug for first-line treatment of HER2-positive
advanced gastric cancer, but the high rate of primary resistance and rapid emergence of …

Metformin is one of the most commonly used first-line oral medications for type 2 diabetes
mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have …

Simple Summary This literature analysis is focused on the pleiotropic action associated with
metformin treatment. Precisely, metformin treatment exerts many health effects, mainly by …

Cancer is one of the major causes of mortality and is the second leading cause of death.
Diabetes mellitus is a serious and growing problem worldwide, and its prevalence continues …

Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

Thyroid cancer has shown a parallel increase with diabetes in the last few years. This
narrative review aims to explain the association between these two entities, focusing on …

The strong evidence of metformin use in subjects affected by type 2 diabetes (T2DM) on
health outcomes, together with data from pre-clinical studies, has led the gerontological …