Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here
we study the cellular composition and hierarchy of the mouse tracheal epithelium by single …

The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However,
BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial …

Classical genetic approaches for interpreting variants, such as case-control or co-
segregation studies, require finding many individuals with each variant. Because the …

In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical
regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus …

During a decade of proof-of-principle analysis in model organisms, protein networks have
been used to further the study of molecular evolution, to gain insight into the robustness of …

The use of networks to integrate different genetic, proteomic, and metabolic datasets has
been proposed as a viable path toward elucidating the origins of specific diseases. Here we …