Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
MT Lin, MF Beal - Nature, 2006 - nature.com
Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …
Oxidative stress and the pathogenesis of Alzheimer′ s disease
Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …
antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a …
Microglial cell dysregulation in brain aging and neurodegeneration
R Von Bernhardi, L Eugenín-von Bernhardi… - Frontiers in aging …, 2015 - frontiersin.org
Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …
phenotypic changes compatible with their activation. Glial activation can lead to …
Brain manganese and the balance between essential roles and neurotoxicity
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer's disease neurons
R Rajmohan, PH Reddy - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
Recent studies of postmortem brains from Alzheimer's disease (AD) patients and transgenic
mouse models of AD suggest that oxidative damage, induced by amyloid β (Aβ), is …
mouse models of AD suggest that oxidative damage, induced by amyloid β (Aβ), is …
Heavy metals exposure and Alzheimer's disease and related dementias
Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …
public health challenges. Risk for Alzheimer's disease and related dementias is partially …
The neuroprotective potentiality of flavonoids on Alzheimer's disease
Alzheimer's disease (AD), due to its spread, has become a global health priority, and is
characterized by senile dementia and progressive disability. The main cause of AD and …
characterized by senile dementia and progressive disability. The main cause of AD and …
Mitochondria take center stage in aging and neurodegeneration
MF Beal - Annals of Neurology: Official Journal of the American …, 2005 - Wiley Online Library
A critical role of mitochondrial dysfunction and oxidative damage has been hypothesized in
both aging and neurodegenerative diseases. Much of the evidence has been correlative, but …
both aging and neurodegenerative diseases. Much of the evidence has been correlative, but …