Comprehensive review of targeted therapy for colorectal cancer
YH **e, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …
Lymphatic vessels in bone support regeneration after injury
Blood and lymphatic vessels form a versatile transport network and provide inductive signals
to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and …
to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and …
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
Development and plasticity of meningeal lymphatic vessels
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …
possible involvement in neuropathological processes, yet little is known about their …
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
EA Korhonen, A Murtomäki, SK Jha… - The Journal of …, 2022 - Am Soc Clin Investig
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
S Huang, CGK Ziegler, J Austin, N Mannoun… - Cell, 2021 - cell.com
Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …
Emerging trends in colorectal cancer: Dysregulated signaling pathways
R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …
most common cause of cancer-related mortality globally. The American Cancer Society …
Cardiac lymphatics in health and disease
E Brakenhielm, K Alitalo - Nature Reviews Cardiology, 2019 - nature.com
The lymphatic vasculature, which accompanies the blood vasculature in most organs, is
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …