Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
[HTML][HTML] The evolution of the concept of stress and the framework of the stress system
S Lu, F Wei, G Li - Cell stress, 2021 - ncbi.nlm.nih.gov
Stress is a central concept in biology and has now been widely used in psychological,
physiological, social, and even environmental fields. However, the concept of stress was …
physiological, social, and even environmental fields. However, the concept of stress was …
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is
overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and …
overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and …
Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
V Gaggioli, CSY Lo, N Reverón-Gómez… - Nature cell …, 2023 - nature.com
Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …
the process of epigenetic reorganization and its implication for fork stability is poorly …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
RAD51 bypasses the CMG helicase to promote replication fork reversal
Replication fork reversal safeguards genome integrity as a replication stress response. DNA
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
[HTML][HTML] Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
I Ceppi, MR Dello Stritto, M Mütze, S Braunshier… - Nature, 2024 - nature.com
DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA
end resection, a process involving the controlled degradation of the 5′-terminated strands …
end resection, a process involving the controlled degradation of the 5′-terminated strands …
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling
Protection of stalled replication forks is crucial for cells to respond to replication stress and
maintain genome stability. Genome instability and replication stress have been linked to …
maintain genome stability. Genome instability and replication stress have been linked to …
Hallmarks of DNA replication stress
Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …
replication machinery is highly accurate, the process of DNA replication is constantly …