The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Organic synthesis is changing; in a world where budgets are constrained and the
environmental impacts of practice are scrutinized, it is increasingly recognized that the …

Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Continuous crystallization is an attractive approach for the delivery of consistent particles
with specified critical quality attributes (CQAs), which are attracting increased interest for the …

This review intends to provide the reader with a clear and concise overview of how
preparative continuous flow organic chemistry could potentially impact on current important …

Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …

The development and operation of the synthesis and workup steps of a fully integrated,
continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical …