The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of “omics” and …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …

In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to
sexual differentiation into gametocytes is essential for transmission to mosquitos. The …

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both …

Obligate intracellular parasites must efficiently invade host cells in order to mature and be
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …

Chemical matter is needed to target the divergent biology associated with the different life
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the …

Periodic fever is a characteristic clinical feature of human malaria, but how parasites survive
febrile episodes is not known. Although the genomes of Plasmodium species encode a full …

A central problem in biology is to identify gene function. One approach is to infer function in
large supergenomic networks of interactions and ancestral relationships among genes; …