Regulation of microtubule dynamics, mechanics and function through the growing tip
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
The four causes: the functional architecture of centromeres and kinetochores
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
Chemical cross-linking with mass spectrometry: a tool for systems structural biology
Highlights•Cross-linking-mass spectrometry constitutes a chemical method to produce
protein complex structural model constraints.•A wide range of sample types are applicable …
protein complex structural model constraints.•A wide range of sample types are applicable …
Higher-order protein assembly controls kinetochore formation
GB Sissoko, EV Tarasovetc, O Marescal… - Nature cell …, 2024 - nature.com
To faithfully segregate chromosomes during vertebrate mitosis, kinetochore–microtubule
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
interactions must be restricted to a single site on each chromosome. Prior work on pair-wise …
Kinase and phosphatase cross-talk at the kinetochore
AT Saurin - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
Composition and organization of kinetochores show plasticity in apicomplexan chromosome segregation
Kinetochores are multiprotein assemblies directing mitotic spindle attachment and
chromosome segregation. In apicomplexan parasites, most known kinetochore components …
chromosome segregation. In apicomplexan parasites, most known kinetochore components …
DNA packaging by molecular motors: from bacteriophage to human chromosomes
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …
A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation
EJ Parnell, EE Jenson, MP Miller - Current Biology, 2024 - cell.com
Accurate chromosome segregation relies on kinetochores carrying out multiple functions,
including establishing and maintaining microtubule attachments, forming precise bi-oriented …
including establishing and maintaining microtubule attachments, forming precise bi-oriented …
Spindle assembly and mitosis in plants
In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that
exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing …
exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing …
Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules
Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …