Hsp70 chaperones: cellular functions and molecular mechanism
MP Mayer, B Bukau - Cellular and molecular life sciences, 2005 - Springer
Hsp70 proteins are central components of the cellular network of molecular chaperones and
folding catalysts. They assist a large variety of protein folding processes in the cell by …
folding catalysts. They assist a large variety of protein folding processes in the cell by …
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
M Stefani, CM Dobson - Journal of molecular medicine, 2003 - Springer
The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic
feature of more than 20 degenerative conditions affecting either the central nervous system …
feature of more than 20 degenerative conditions affecting either the central nervous system …
Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
Protein homeostasis and aging: The importance of exquisite quality control
All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …
and functional proteome. A progressive deterioration in the ability of cells to preserve the …
Cellular strategies of protein quality control
B Chen, M Retzlaff, T Roos… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Eukaryotic cells must contend with a continuous stream of misfolded proteins that
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto… - Nature structural & …, 2015 - nature.com
Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose
pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42) …
pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42) …
Hsp70 reduces α-synuclein aggregation and toxicity
Aggregation and cytotoxicity of misfolded α-synuclein is postulated to be crucial in the
disease process of neurodegenerative disorders such as Parkinson's disease and DLB …
disease process of neurodegenerative disorders such as Parkinson's disease and DLB …
Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
Stress-response pathways have evolved to maintain cellular homeostasis and to ensure the
survival of organisms under changing environmental conditions. Whereas severe stress is …
survival of organisms under changing environmental conditions. Whereas severe stress is …
Huntingtin and the molecular pathogenesis of Huntington's disease: Fourth in Molecular Medicine Review Series
Huntington's disease (HD) is a late-onset neurodegenerative disorder that is caused by a
CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine …
CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine …