Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms

M Ghasemi, M Navidhamidi, F Rezaei… - Cognitive, Affective, & …, 2022 - Springer
The hippocampus has been implicated in modulating anxiety. It interacts with a variety of
brain regions, both cortical and subcortical areas regulating emotion and stress responses …

Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly

L Chen, X Li, M Tjia, S Thapliyal - Current opinion in neurobiology, 2022 - Elsevier
In this review, we discuss the significance of the synaptic excitation/inhibition (E/I) balance in
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …

Cortical circuit dynamics are homeostatically tuned to criticality in vivo

Z Ma, GG Turrigiano, R Wessel, KB Hengen - Neuron, 2019 - cell.com
Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives
rise to balanced network dynamics is unknown. Here, we continuously monitored the …

LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment

H Jung, D Lee, H You, M Lee, H Kim, E Cheong… - Scientific reports, 2023 - nature.com
Neuroinflammation impacts the brain and cognitive behavior through microglial activation. In
this study, we determined the temporal sequence from microglial activation to synaptic …

[HTML][HTML] Regulation of circuit organization and function through inhibitory synaptic plasticity

YK Wu, C Miehl, J Gjorgjieva - Trends in Neurosciences, 2022 - cell.com
Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …

Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics

M Valero, I Zutshi, E Yoon, G Buzsáki - Science, 2022 - science.org
Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …

What is the dynamical regime of cerebral cortex?

Y Ahmadian, KD Miller - Neuron, 2021 - cell.com
Many studies have shown that the excitation and inhibition received by cortical neurons
remain roughly balanced across many conditions. A key question for understanding the …

More than just summed neuronal activity: how multiple cell types shape the BOLD response

C Howarth, A Mishra, CN Hall - … Transactions of the …, 2021 - royalsocietypublishing.org
Functional neuroimaging techniques are widely applied to investigations of human cognition
and disease. The most commonly used among these is blood oxygen level-dependent …

What is excitation/inhibition and how is it regulated? A case of the elephant and the wisemen

H He, HT Cline - Journal of Experimental Neuroscience, 2019 - journals.sagepub.com
The balance between excitation and inhibition in neuronal circuits has drawn more and
more attention in recent years, due to its proposed multifaceted functions in the normal …

Inhibitory control in neuronal networks relies on the extracellular matrix integrity

E Dzyubenko, M Fleischer… - Cellular and Molecular …, 2021 - Springer
Inhibitory control is essential for the regulation of neuronal network activity, where excitatory
and inhibitory synapses can act synergistically, reciprocally, and antagonistically. Sustained …