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Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms
The hippocampus has been implicated in modulating anxiety. It interacts with a variety of
brain regions, both cortical and subcortical areas regulating emotion and stress responses …
brain regions, both cortical and subcortical areas regulating emotion and stress responses …
Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly
In this review, we discuss the significance of the synaptic excitation/inhibition (E/I) balance in
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …
Cortical circuit dynamics are homeostatically tuned to criticality in vivo
Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives
rise to balanced network dynamics is unknown. Here, we continuously monitored the …
rise to balanced network dynamics is unknown. Here, we continuously monitored the …
LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment
H Jung, D Lee, H You, M Lee, H Kim, E Cheong… - Scientific reports, 2023 - nature.com
Neuroinflammation impacts the brain and cognitive behavior through microglial activation. In
this study, we determined the temporal sequence from microglial activation to synaptic …
this study, we determined the temporal sequence from microglial activation to synaptic …
[HTML][HTML] Regulation of circuit organization and function through inhibitory synaptic plasticity
Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …
What is the dynamical regime of cerebral cortex?
Y Ahmadian, KD Miller - Neuron, 2021 - cell.com
Many studies have shown that the excitation and inhibition received by cortical neurons
remain roughly balanced across many conditions. A key question for understanding the …
remain roughly balanced across many conditions. A key question for understanding the …
More than just summed neuronal activity: how multiple cell types shape the BOLD response
Functional neuroimaging techniques are widely applied to investigations of human cognition
and disease. The most commonly used among these is blood oxygen level-dependent …
and disease. The most commonly used among these is blood oxygen level-dependent …
What is excitation/inhibition and how is it regulated? A case of the elephant and the wisemen
The balance between excitation and inhibition in neuronal circuits has drawn more and
more attention in recent years, due to its proposed multifaceted functions in the normal …
more attention in recent years, due to its proposed multifaceted functions in the normal …
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
E Dzyubenko, M Fleischer… - Cellular and Molecular …, 2021 - Springer
Inhibitory control is essential for the regulation of neuronal network activity, where excitatory
and inhibitory synapses can act synergistically, reciprocally, and antagonistically. Sustained …
and inhibitory synapses can act synergistically, reciprocally, and antagonistically. Sustained …