Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Cellular agriculture is an emerging scientific discipline that leverages the existing principles
behind stem cell biology, tissue engineering, and animal sciences to create agricultural …

Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite
profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …

Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

Fibro-adipogenic progenitors (FAPs) play a crucial role in skeletal muscle regeneration, as
they generate a favorable niche that allows satellite cells to perform efficient muscle …

Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily
mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted …

Abstract Background Satellite cells (SCs) are critical to skeletal muscle regeneration.
Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is …