Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …

Ovarian cancer is the most common malignant tumors of the female reproductive system,
and its standard treatments are cytoreductive surgery and platinum-based adjuvant …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive
malignancy. Recent multi-gene analysis approaches such as next-generation sequencing …

Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of
extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the …

The resolution and dimensionality with which biologists can characterize cell types have
expanded dramatically in recent years, and intersectional consideration of such features (eg …

Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma,
which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are …

Pancreatic ductal adenocarcinoma (PDAC), a lethal disease, requires a grasp of its biology
for effective therapies. Exosomes, implicated in cancer, are poorly understood in living …

Intratumoral heterogeneity and cellular plasticity have emerged as hallmarks of cancer,
including pancreatic ductal adenocarcinoma (PDAC). As PDAC portends a dire prognosis, a …

While numerous approaches have been reported towards understanding single cell
regulation, there is limited understanding of single cell production of extracellular matrix …

Site-specific recombinases (SSR) are utilized as important genome engineering tools to
precisely modify the genome of mice and other model organisms. Reporter mice that mark …