Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlap** pathologic processes activate a common pathway consisting of endothelial cell …

Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

The comparison of the immunological state of pregnancy to an immunosuppressed host–
graft model continues to lead research and clinical practice to ill-defined approaches. This …

Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus
must be supported within the pregnant female for the required gestational period …

At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …

Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the …