Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …

Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of
millions of people in the develo** world. We have sequenced the∼ 90 megabase (Mb) …

Most phytoparasitic nematodes infect plant roots and some species have evolved
sophisticated interactive relationships with host cells to sustain a sedentary parasitic habit …

For more than four decades, the free-living nematode Caenorhabditis elegans has been
extensively used in anthelmintic research. Classic genetic screens and heterologous …

Background Since the advent of ivermectin (along with melarsomine and doxycycline),
heartworm has come to be viewed as a solved problem in veterinary medicine, diminishing …

Plant parasitic nematodes have been, so far, refractory to transformation or mutagenesis.
The functional analysis of nematode genes relies on the development of reverse genetic …

Heterorhabditis bacteriophora are entomopathogenic nematodes that have evolved a
mutualism with Photorhabdus luminescens bacteria to function as highly virulent insect …

Nematodes belong to one of the most diverse animal phyla. However, functional genomic
studies in nematodes, other than in a few species, have often been limited in their reliability …

Recent transcriptome and genome projects have dramatically expanded the biological data
available across the phylum Nematoda. Here we summarize analyses of these sequences …