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Role of regulatory T cells during virus infection
The host response to viruses includes multiple cell types that have regulatory function. Most
information focuses on CD 4+ regulatory T cells that express the transcription factor Foxp3+ …
information focuses on CD 4+ regulatory T cells that express the transcription factor Foxp3+ …
The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis
SUMMARY Human alphaherpesvirus 1 (HSV-1) is a highly successful neurotropic pathogen
that primarily infects the epithelial cells lining the orofacial mucosa. After primary lytic …
that primarily infects the epithelial cells lining the orofacial mucosa. After primary lytic …
Consensus on the key characteristics of immunotoxic agents as a basis for hazard identification
DR Germolec, H Lebrec, SE Anderson… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Key characteristics (KCs), properties of agents or exposures that confer
potential hazard, have been developed for carcinogens and other toxicant classes. KCs …
potential hazard, have been developed for carcinogens and other toxicant classes. KCs …
Pathogenesis of herpes stromal keratitis: immune inflammatory response mediated by inflammatory regulators
L Wang, R Wang, C Xu, H Zhou - Frontiers in immunology, 2020 - frontiersin.org
Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even
blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is …
blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is …
High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from …
Background Cross-reactive SARS-CoV-2-specific memory CD4+ and CD8+ T cells are
present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However …
present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However …
Characterization of resident corneal plasmacytoid dendritic cells and their pivotal role in herpes simplex keratitis
The presence and potential functions of resident plasmacytoid dendritic cells (pDCs) in
peripheral tissues is unclear. We report that pDCs constitutively populate naïve corneas and …
peripheral tissues is unclear. We report that pDCs constitutively populate naïve corneas and …
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice
During viral infection, inflammation and recovery are tightly controlled by competing
proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the …
proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the …
Role of innate interferon responses at the ocular surface in herpes simplex virus-1-induced herpetic stromal keratitis
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that primarily infects
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …
epithelial cells of the orofacial mucosa. After initial lytic replication, HSV-1 enters sensory …
Interplay of regulatory T cell and Th17 cells during infectious diseases in humans and animals
It is now clear that the outcome of an inflammatory process caused by infections depends on
the balance of responses by several components of the immune system. Of particular …
the balance of responses by several components of the immune system. Of particular …
Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets
Despite encouraging progresses achieved in the management of viral diseases, efficient
strategies to counteract infections are still required. The current global challenge highlighted …
strategies to counteract infections are still required. The current global challenge highlighted …