The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

American Association of Clinical Endocrinology clinical practice guideline: develo** a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

The Lancet Commission on diabetes: using data to transform diabetes care and patient lives

JCN Chan, LL Lim, NJ Wareham, JE Shaw, TJ Orchard… - The Lancet, 2020 - thelancet.com
Executive summary 2020 will go down in history as the year when the global community was
awakened to the fragility of human health and the interdependence of the ecosystem …

The relationship between diabetes mellitus and cancers and its underlying mechanisms

B Zhu, S Qu - Frontiers in Endocrinology, 2022 - frontiersin.org
Epidemiological studies suggest associations between diabetes mellitus and some cancers.
The risk of a number of cancers appears to be increased in diabetes mellitus. On the other …

Diabetes, obesity, and cancer—pathophysiology and clinical implications

IC Lega, LL Lipscombe - Endocrine reviews, 2020 - academic.oup.com
Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

[HTML][HTML] Diabetes and cancer: risk, challenges, management and outcomes

RK Shahid, S Ahmed, D Le, S Yadav - Cancers, 2021 - mdpi.com
Simple Summary Diabetes mellitus is a common disease in patients with cancer. It is a risk
factor for certain cancers such as pancreatic, liver, colon, breast, and endometrial cancer …

Insulin resistance and cancer: in search for a causal link

E Chiefari, M Mirabelli, S La Vignera… - International journal of …, 2021 - mdpi.com
Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus

A Herms, B Colom, G Piedrafita, A Kalogeropoulou… - Nature Genetics, 2024 - nature.com
Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …